Testing nitrous oxide for depression brain circuit activity
Treatments studied
Part of Mental health clinical trials.
This early study tests whether nitrous oxide, aimed at specific brain circuits, can change depression-related brain activity. It is mainly for adults with major depression or treatment-resistant depression, and includes brain imaging during the study.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be an adult age 18 to 65
- Be right-handed
- Be able to speak and understand English well
- For depression groups: score high or low on a depression rating test (HDRS) as required, based on whether you have treatment-resistant depression
- Not have other major mental health diagnoses besides depression (this is checked by interview and records)
- Be able to safely have MRI scans (not blocked by metal/implants or severe claustrophobia)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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