Treatment
Nitrous Oxide clinical trials
We’re tracking 16 recruiting studies that include Nitrous Oxide, each written for real people, not researchers, below.
Recruiting studies
- NCT07690358Recruiting
Nitrous oxide levels in body after different exposures
This study measures how much nitrous oxide (laughing gas) stays in your blood, breath, and urine after different types of exposure. It helps researchers understand how long the gas remains in the body for safety reasons.
AarhusAges 18–65 - NCT05540561Recruiting
Testing and monitoring for nitrous oxide use
This study looks at how nitrous oxide (also called laughing gas) is detected and how health effects may show up over time. It may help doctors better diagnose problems early and track changes after use.
BéthuneAges 14–65 - NCT06118567RecruitingPhase 2
Does nitrous oxide help with aggression?
This study tests if a single dose of nitrous oxide (laughing gas) can reduce aggression in people with intermittent explosive disorder (IED). It compares their reactions to healthy volunteers without aggression issues.
Columbus, OhioAges 21–55 - NCT03826693RecruitingPhase 2
Nitrous oxide trial for obsessive-compulsive disorder symptoms
This Phase 2 pilot study tests whether breathing nitrous oxide (laughing gas) can reduce symptoms of obsessive-compulsive disorder (OCD). It compares what happens during a treatment-free period and then during the study treatment to see if symptoms improve.
Stanford, CaliforniaAges 18–65 - NCT03736538Enrolling by invitationPhase 1
Nitrous oxide for suicidal thoughts in depression
This Phase 1 study tests whether breathing nitrous oxide can safely reduce suicidal thoughts in adults with major depression. It may help people whose depression is causing moderate to severe suicidal thinking, by studying a fast-acting treatment approach.
St Louis, MissouriAges 18–65 - NCT06636357RecruitingPhase 2
Laughing gas for acute suicidal thoughts
This study tests whether breathing a mixture of nitrous oxide (laughing gas) and oxygen can quickly reduce strong suicidal thoughts. It's for people experiencing a mental health crisis who may need fast relief.
ZurichAges 18–65 - NCT02994433RecruitingPhase 1
Testing nitrous oxide for depression brain circuit activity
This early study tests whether nitrous oxide, aimed at specific brain circuits, can change depression-related brain activity. It is mainly for adults with major depression or treatment-resistant depression, and includes brain imaging during the study.
St Louis, MissouriAges 18–65 - NCT03695887RecruitingEarly Phase 1
Disposable nitrous oxide for pain during burn dressing changes
This early-stage study tests whether using disposable nitrous oxide canisters can better control pain when you need burn dressing changes. It may help by making dressing changes more comfortable, but eligibility depends on your burn size, health, and breathing ability.
Winnipeg, ManitobaAges 18 years+ - NCT05895383RecruitingPhase 4
Nitrous oxide breathing during vasectomy: a feasibility study
This study looks at whether self-adjusting nitrous oxide (a calming gas) with oxygen can be safely and comfortably used during a vasectomy, and how people experience it. You may be offered the gas to see how it fits into care during the procedure.
Boston, MassachusettsAges 21–85 - NCT07473206Recruiting
Laughing gas for pain during office hysteroscopy
This study tests whether using laughing gas (nitrous oxide) plus a calming video on a screen can reduce pain and anxiety during a quick procedure to look inside the uterus (hysteroscopy). If you are having this procedure, the trial may help you feel more comfortable.
BiellaAges 25–60 - NCT07618676Recruiting
Nitrous Oxide vs Lidocaine for Pain Relief During Needle Procedures
This study compares two pain-relief methods—nitrous oxide gas (laughing gas) and lidocaine numbing cream—to see which works better when doctors need to place a needle in your vein. If you've never used nitrous oxide before and are generally healthy, you may be a good fit.
Belgrade, Savski VenacAges 18–65 - NCT07245628RecruitingEarly Phase 1
Self-adjusting nitrous vs. placebo for office vasectomy
This trial compares self-administered nitrous oxide gas with a placebo to see if it helps reduce pain and anxiety during a vasectomy done in the doctor's office. It aims to find a better way to manage discomfort without stronger medications.
Boston, MassachusettsAges 18–85 - NCT05383495RecruitingPhase 3
Calming medicine during child laceration repair
This trial tests a calming/anxiety-reducing medicine to see if it helps children feel less scared during stitches for a skin cut. It may help make the repair process easier for children and their caregivers.
London, OntarioAges 2–12 - NCT06557642Recruiting
Laughing Gas and Emotional Thinking Study
This study tests how nitrous oxide (laughing gas) affects your emotions and thinking. It's looking for healthy volunteers ages 18 to 40 to see how the gas might change emotional processing.
OxfordAges 18–40 - NCT05714917Recruiting
Studying recovery after nerve damage from NOS use
This study looks at how neurological symptoms (like numbness, weakness, unsteadiness, or walking problems) recover after damage caused by NOS use. It may help researchers understand what recovery looks like and what support or treatments could work best.
BirminghamAges 16–40 - NCT06928740Recruiting
Music app vs. gas for anxiety during back injection
This trial tests whether listening to a digital music app can reduce anxiety as well as a standard gas (laughing gas) does in people getting a CT-guided back injection for low back pain.
NîmesAges 18 years+
What Nitrous Oxide is being studied for
Conditions with recruiting Nitrous Oxide studies.
Common questions
- Are there clinical trials studying Nitrous Oxide?
- Yes. Clin2 currently lists 16 recruiting studies that include Nitrous Oxide, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Nitrous Oxide trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Nitrous Oxide an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Nitrous Oxide or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.