Laughing gas for depression: a mood improvement trial
Part of Mental health clinical trials.
This study tests if laughing gas (nitrous oxide) can safely improve mood in adults with depression who haven't gotten better after trying two antidepressant medicines. It may offer a new option for treatment-resistant depression.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old
- You have been diagnosed with major depression by a doctor
- Your current depression is moderate to severe, with a score above 21 on a depression rating scale
- You have tried at least two different antidepressants for your current episode but they didn't work well enough
- You are not pregnant or breastfeeding and, if you could become pregnant, you agree to use effective birth control
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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