Cord blood transplant for severe aplastic anemia or MDS
Part of Blood & lymphatic clinical trials.
This trial tests a special type of cord blood transplant using lab-grown stem cells to help the new blood-forming cells “take” sooner. It’s for people with severe aplastic anemia or certain MDS cases who have not responded well to standard immune-suppressing treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe aplastic anemia (bone marrow under 30% cellularity) with low white blood cell counts and/or needing red blood cell or platelet transfusions, OR you had severe aplastic anemia that turned into MDS with specific risk and marrow/blast counts.
- You have not responded well to immune-suppressing therapy (like ATG and cyclosporine, and/or cyclosporine with eltrombopag if you couldn’t get ATG or couldn’t tolerate it).
- You must have a backup donor option available, such as a compatible haploidentical or matched unrelated donor, or extra cord blood units if the main cord unit isn’t usable.
- You need access to an eligible cord blood unit from a national bank with good matching and enough cell quantity (there are special rules if the total cell amount is lower but CD34 cell counts are high).
- You must be between ages 4 and 60 and be able to understand the study (parents/guardians help with consent for ages 4–17).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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