Modified Stem Cell Transplant for Severe Aplastic Anemia
Part of Blood & lymphatic clinical trials.
This trial tests a new way to prepare the body for a donor stem cell transplant (allogeneic transplant) in people with severe aplastic anemia or other blood diseases. The goal is to make the transplant safer and more effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a blood disease (like aplastic anemia, leukemia, or lymphoma) and your doctor says you need a stem cell transplant.
- You are between 3 and 65 years old, and your weight is between 22 and 220 pounds (10–100 kg).
- Your heart, liver, and kidneys are working well enough for the procedure.
- You do not have a serious infection or any major organ damage.
- You are not pregnant and do not have a mental health condition that would make it hard to participate.
- You have not had a stem cell transplant before, and your doctor thinks you are a good match for this study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
This trial tests whether an early bone marrow transplant from a half-matched family member or an unrelated donor can help people with severe aplastic anemia. It aims to restore the body's ability to make healthy blood cells.
This trial tests a new way to treat severe aplastic anemia by combining a stem cell transplant from a half-matched donor with special stem cells from umbilical cord blood. The goal is to help your body make healthy blood cells again.
This Phase 2 study tests a specific type of donor stem cell transplant for severe bone marrow failure conditions, aiming to improve cure rates while reducing transplant risks. It includes people with diseases like severe aplastic anemia and certain bone marrow disorders, especially when standard transplant plans feel too risky.
This study tests a new combination of drugs to prepare older patients (40–60 years old) with severe aplastic anemia for a stem cell transplant from a half-matched donor. The goal is to make the transplant safer and more effective for this age group.
This Phase 2 study tests a bone marrow transplant from a closely matched related donor, plus medicine after the transplant to help prevent immune complications. It may be an option if you have severe aplastic anemia and meet specific health and lab requirements.
This trial tests a stem cell transplant using a milder conditioning regimen and a drug called post-transplant cyclophosphamide to treat severe aplastic anemia and other acquired bone marrow failure conditions. The goal is to help patients achieve a functioning donor bone marrow with fewer side effects.
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