Bone marrow transplant for children with aplastic anemia
Part of Blood & lymphatic clinical trials.
This trial tests whether giving children with aplastic anemia a transplant using a matched unrelated donor (a bone marrow donor who is not a family member) can help treat their condition. It aims to see if this approach is effective and safe for children who qualify.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be under 18 years old.
- Have a diagnosis of severe or moderate aplastic anemia that needs treatment.
- Have a matched unrelated donor available (donor matches on 10 key tissue traits).
- Be generally healthy enough for a transplant (good daily function, no severe infections, and working liver and kidneys).
- Have health insurance.
- For teens who can have children, use effective birth control during the study.
- Parents or guardians must agree in writing, and the child's agreement is also asked if age-appropriate.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether an early bone marrow transplant from a half-matched family member or an unrelated donor can help people with severe aplastic anemia. It aims to restore the body's ability to make healthy blood cells.
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This Phase 2 study tests a bone marrow transplant from a closely matched related donor, plus medicine after the transplant to help prevent immune complications. It may be an option if you have severe aplastic anemia and meet specific health and lab requirements.
This trial tests a new way to prepare the body for a donor stem cell transplant (allogeneic transplant) in people with severe aplastic anemia or other blood diseases. The goal is to make the transplant safer and more effective.
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This trial tests a stem cell transplant using a milder conditioning regimen and a drug called post-transplant cyclophosphamide to treat severe aplastic anemia and other acquired bone marrow failure conditions. The goal is to help patients achieve a functioning donor bone marrow with fewer side effects.
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