Avoiding blood thinners after brain bleeding in atrial fibrillation
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This Phase 3 trial studies whether it’s safer to avoid long-term blood thinners after a spontaneous brain bleed in people with atrial fibrillation (an irregular heart rhythm). It compares different prevention strategies to lower the risk of stroke or other blood-vessel problems without causing new, serious bleeding.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult (18 or older).
- You have atrial fibrillation that is not from a heart valve problem (confirmed on an ECG).
- You had a spontaneous brain bleed (intracerebral hemorrhage) seen on CT or MRI more than 14 days ago.
- Your doctor says you are usually advised to take long-term blood thinning to prevent stroke, based on your risk score being 2 or higher.
- You don’t have severe disability from the brain bleed (modified Rankin score is not 4 or 5).
- You can safely take one of the study options (including either a procedure to close part of the heart or the medication apixaban), and you’re willing to do it.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This study looks at how to better predict both stroke risk and bleeding risk in people with atrial fibrillation. It may help doctors choose safer blood-thinner treatment and follow-up plans.
This trial tests if starting blood thinners can prevent another stroke in people who had a stroke but were found to have a hidden heart rhythm problem called atrial fibrillation. It is for older adults who have had a recent stroke without a known cause.
This Phase 3 study tests whether a blood thinner (apixaban) can help prevent another stroke and support recovery after you’ve had a brain bleed. You would be assigned to a treatment group, and the study checks safety and whether strokes can be reduced without causing dangerous bleeding.
This study tests whether patients with atrial fibrillation (a heart rhythm disorder) who have had both a previous brain bleed and a recent stroke can safely take blood thinners to prevent future strokes. Researchers want to find the safest approach for people in this high-risk situation.
This trial studies a way to help protect the brain during a catheter procedure that closes the left atrial appendage (a small heart pouch) in people with atrial fibrillation. It may help lower the risk of stroke-related brain injury for patients who can’t safely take blood thinners.
This trial tests whether patients who receive a special device to close a hole in the heart (to prevent stroke from irregular heartbeat) can safely take fewer blood-thinning medications afterward. The study compares taking a standard blood thinner for 3 months versus taking aspirin only, to see which approach works best with fewer bleeding risks.
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