Early mitral valve repair versus watchful waiting
Part of Heart & circulation clinical trials.
This trial compares doing mitral valve repair early versus closely monitoring without surgery in people who have severe leakage but no symptoms. It aims to see whether early repair helps prevent future heart problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe “mitral regurgitation” (mitral valve leakage) from valve leaflet prolapse seen on an ultrasound of the heart
- You currently have no symptoms, or your symptoms are uncertain and an exercise test/check shows you’re truly not symptomatic
- Your heart’s pumping strength is preserved (left ejection fraction 60% or higher) and the left heart chamber size is within limits (end-systolic diameter 40 mm or less)
- Your heart rhythm is normal sinus rhythm on the screening ECG
- Your lung/pulmonary pressure estimate is not too high (pulmonary artery pressure 50 mmHg or less on echo)
- Your doctors think your valve repair is likely to succeed, and your surgical risk score is low (EuroSCORE II 3% or less)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares two approaches for people with a leaking aortic valve but no symptoms: early surgery or careful monitoring (“watchful waiting”). It aims to see which strategy better prevents future heart problems and when surgery is most helpful.
This trial compares a less invasive catheter procedure to the standard surgical operation to treat “secondary” leaking of the mitral valve. It may help people with significant valve leak decide which approach works better for reducing symptoms and heart strain.
This trial compares doing mitral valve repair early with closely monitoring symptoms instead, for people who have severe leakage but feel well. It may help determine whether early surgery prevents future heart problems without causing unnecessary risk.
This study looks at how long a new mitral valve treatment/device can stay working in people with moderate-to-severe or severe mitral valve leak. It may help avoid or delay surgery for people considered higher risk for mitral valve repair.
This trial tests a new way to repair a leaky mitral valve without stopping the heart or using a heart-lung machine. The surgery is done through a small cut in the heart's lower chamber. It may be an option for people with severe degenerative mitral regurgitation who are not good candidates for standard open-heart surgery.
This trial studies severe secondary mitral valve leaking and uses heart imaging to predict how well the heart and symptoms improve after a less-invasive valve procedure. It may help doctors better forecast who benefits most from this repair.
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