Tracking brain changes in probable Lewy body dementia
Part of Brain & nervous system, Mental health clinical trials.
This trial follows people with probable Lewy body dementia over several years to see how the brain changes on MRI and on memory/thinking tests. It may help researchers understand disease progression and improve future care for Lewy body dementia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be at least 18 years old and have a “probable” diagnosis of Lewy body dementia
- Have a reliable caregiver/informant who can regularly talk with or see you at least weekly
- Be able to speak and understand English well enough for the study and consent
- Be willing to return for up to 6 visits over about 5 years and have yearly follow-up
- Be willing and able to complete memory/thinking (neuropsychological) testing
- Be able to have MRI scans (no MRI safety issues)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how brain function changes over time in people with Lewy body disease or Alzheimer's. Researchers will use memory tests, MRI scans, and EEG (a painless brain-wave recording) to track these changes, and you will need a family member or friend to help report on your daily life.
This early-stage study tests whether ambroxol can act as a “disease-modifying” treatment for Lewy body dementia, meaning it aims to change how the illness progresses rather than only relieve symptoms. You may be asked to complete brain testing and have stable medications while the study monitors memory, thinking, and safety.
This trial looks at brain wave patterns (EEG) and nerve damage in people with Lewy body disease. It uses past data from a study called Alpha-Lewy-MA and a special test (RT-QuIC) to learn more about the disease.
This study uses brain scans and a spinal fluid test to better understand memory and thinking changes in different groups, from people with healthy thinking to early or established dementia. If you qualify, it may help researchers learn what’s driving these conditions and how they progress.
This study tests an experimental drug (LY3954068) for people with early Alzheimer's disease. It aims to see if the drug is safe and may slow memory loss. You'll need a PET scan to measure tau protein in the brain and have a study partner who can help attend appointments.
This study looks at how brain changes affect attention and thinking in people with Lewy body dementia. It includes brain scans, an EEG, and a medication option to see if it helps with symptoms.
Hear when a new Lewy Body Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.