Brain function study in Lewy body and Alzheimer's disease
Part of Brain & nervous system, Mental health clinical trials.
This study looks at how brain function changes over time in people with Lewy body disease or Alzheimer's. Researchers will use memory tests, MRI scans, and EEG (a painless brain-wave recording) to track these changes, and you will need a family member or friend to help report on your daily life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must speak English as your main language.
- You are either healthy or have a diagnosis of Lewy body disease or Alzheimer's from a neurologist.
- You are willing to do memory and thinking tests, plus an MRI brain scan and an EEG (a test that records your brain waves).
- You do not have metal implants like a pacemaker, brain stimulator, or aneurysm clip, and you are not claustrophobic in MRI machines.
- You have not had a stroke, epilepsy, brain tumor, severe head injury, or other major brain condition besides Lewy body or Alzheimer's.
- You should be able to bring a study partner (a family member or friend) who knows your day-to-day life.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial follows people with probable Lewy body dementia over several years to see how the brain changes on MRI and on memory/thinking tests. It may help researchers understand disease progression and improve future care for Lewy body dementia.
This study uses a combination of tests to improve diagnosis of dementia with Lewy bodies compared to Alzheimer's disease and healthy aging. You may help doctors identify the right diagnosis more accurately.
This study uses an advanced EEG (electroencephalogram) to measure brain wave activity in people with early Alzheimer's, frontotemporal dementia, or Lewy body dementia. It aims to find patterns that could help doctors better understand the disease and predict how it might progress.
This trial looks at brain wave patterns (EEG) and nerve damage in people with Lewy body disease. It uses past data from a study called Alpha-Lewy-MA and a special test (RT-QuIC) to learn more about the disease.
This study helps people understand a protein called alpha-synuclein that may be related to memory problems and movement disorders. Researchers will either test your spinal fluid or skin to look for this protein, then discuss the results with you and measure how you're doing over time.
This early-stage study tests whether ambroxol can act as a “disease-modifying” treatment for Lewy body dementia, meaning it aims to change how the illness progresses rather than only relieve symptoms. You may be asked to complete brain testing and have stable medications while the study monitors memory, thinking, and safety.
Hear when a new Lewy Body Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.