Watchful waiting then chemotherapy before surgery for rectal cancer
Part of Cancer, Digestive system clinical trials.
This trial studies whether a period of active surveillance (watching closely) and chemotherapy before surgery can improve outcomes for people with stage II–III rectal cancer. You would also receive standard chemo-radiation if you qualify, then proceed to surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have confirmed rectal cancer that starts in the rectum and is not a recurrence
- Your cancer is in stage II or III and can be removed with curative surgery
- Your tumor is within 12 cm of the anus, based on exam, endoscopy, or MRI
- Your cancer in the lymph nodes is limited to the area planned for radiation
- You are well enough for treatment (ECOG 0–2) and can return for all study visits
- You cannot have had prior radiation to the pelvis and cannot have inflammatory bowel disease
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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