Chemo before rectal surgery, without pelvic radiation
Part of Cancer, Digestive system clinical trials.
This Phase 3 study tests whether giving chemotherapy before rectal surgery can work as well as standard treatment that usually includes pelvic radiation. It aims to reduce the need for pelvic radiation while still keeping the cancer under control.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have rectal cancer located in the middle or lower rectum (not more than 10 cm from the anus on MRI).
- Your scan shows specific cancer depth and lymph node status (cT3N0 and/or cT1–T3N+), but not the most advanced cT4 stage.
- Your MRI must show a “safe margin” around the tumor: circumferential margin is greater than 2 mm.
- You are at least 18 years old, and your overall function is good (ECOG/WHO performance status 0 or 1).
- You cannot have cancer that has spread to other organs (no metastatic disease).
- You must be able to take the study chemo drugs (including 5-FU or related medicines) and you cannot have certain medication or health contraindications.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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