Fetal airway blockage procedure for severe CDH during pregnancy
Part of Genetic & congenital clinical trials.
This trial studies a procedure done before birth that partially blocks the baby’s windpipe to help lung development in babies with diaphragmatic hernia. It may help babies with severe lung underdevelopment, but only if specific pregnancy and baby factors are met.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are pregnant and at least 18 years old, and you can give informed consent
- Your pregnancy involves one baby (singleton pregnancy)
- Your baby has a confirmed, isolated left- or right-sided CDH (diaphragm hernia) with the liver in the chest area
- Your baby’s chromosomes (karyotype) are normal, and you enroll before 29 weeks plus 6 days
- The ultrasound shows severe underdeveloped lungs (specific LHR/side limits must be met)
- You must not have reasons that make the procedure unsafe or impossible (for example, certain uterine/placenta risks, latex allergy, or cannot stay for the required care timeline)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial studies a fetal procedure called FETO that places a small balloon in the baby’s windpipe to help the lungs grow in severe congenital diaphragmatic hernia (CDH). It may help babies with very small lung development after birth, but you must meet specific pregnancy, genetic, and safety requirements.
This trial tests a procedure called FETO (fetoscopic endoluminal tracheal occlusion) performed during pregnancy to help babies with congenital diaphragmatic hernia—a birth defect where part of the diaphragm (breathing muscle) has a hole and organs from the belly move into the chest. The procedure temporarily blocks the baby's windpipe to help the lungs grow bigger before birth.
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