Testing naldemedine for constipation caused by opioid pain meds
Part of Mental health clinical trials.
This study tests whether naldemedine is safe and how the body processes it in children who take opioid medicines and are dealing with constipation or are at risk for it. It may help some children by reducing constipation side effects from opioid pain treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have cancer or non-cancer pain and you are taking opioids now or about to start them
- You have constipation that is new, or a past history of constipation treated with laxatives, or constipation is expected after opioids
- You (or your child) can stay at the clinic for blood draws for at least 12 hours after the first dose, and return at 24 hours
- Child’s growth is within a healthy range for age (BMI roughly the 3rd to 97th percentiles)
- You do not have a recent or planned surgery in the gut (within the last year for past surgery, or upcoming surgery)
- You do not have signs of a blocked or perforation-risk gut (for example, obstruction) and can eat or swallow normally
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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