Serial amnioinfusions for severe fetal kidney underdevelopment
Treatments studied
Part of Genetic & congenital clinical trials.
This Phase 1 study tests whether repeatedly adding fluid into the amniotic sac (amnioinfusion) can help babies with very severe kidney problems before birth. The goal is to see if this “regenerative therapy” is safe and potentially beneficial, while closely tracking pregnancy and baby outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are pregnant with one baby (singleton) and you are over 18 years old.
- Your baby is under 26 weeks along and has severe urinary/kidney failure from LUTO or bilateral kidney agenesis (not having kidneys).
- Your baby does not have chromosome problems and does not have other birth defects besides the kidney/urinary issue.
- Your own blood tests are negative for hepatitis B, hepatitis C, and HIV.
- You must be able and willing to return for travel and follow-up visits, and you must agree to invasive testing if required.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial is testing whether adding fluid back into the womb (amnioinfusion) can help babies whose kidneys are not working and who have no amniotic fluid early in pregnancy. It may improve the baby's chances of survival and lung development.
This trial studies a fetal cystoscopy procedure to treat severe urinary tract blockage in a baby boy during pregnancy. It aims to see whether the procedure helps improve outcomes, but it requires specific pregnancy conditions and testing beforehand.
This trial tests a minimally invasive surgery (fetal cystoscopy) performed during pregnancy to help male babies with severe bladder obstruction. The goal is to prevent kidney damage and improve outcomes after birth.
This study checks whether a specific kidney test (a renogram scan) can detect a significant urine blockage early in babies born with ureter-pelvic junction obstruction (a narrow connection between the kidney and ureter). It may help clinicians decide sooner which babies need closer follow-up or treatment.
This study tests a standardized plan of prenatal (during pregnancy) care for pregnancies where the baby has LUTO, regardless of when the diagnosis was made. It may help families by testing whether consistent prenatal monitoring and management improves outcomes for babies with this condition.
This study observes babies with fluid in the kidney (hydronephrosis) over 3 years to understand how the condition naturally progresses without intervention. Participation involves regular ultrasounds and check-ups.
Hear when a new Lower Urinary Tract Obstructive Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.