Antifungal drugs for recurrent brain tumors
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This early-phase trial tests whether two antifungal drugs, ketoconazole and posaconazole, can help treat recurrent high-grade gliomas when taken by mouth before surgery. The goal is to see if these drugs can reach the tumor and slow its growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- Your brain tumor (high-grade glioma) has come back and a doctor says it needs to be removed with surgery.
- You are generally well enough to care for yourself (Karnofsky score of 60% or higher, ECOG 2 or less).
- Your liver and kidney function are within acceptable ranges, and you can swallow pills.
- You have not taken an azole antifungal (like ketoconazole or posaconazole) in the last 3 months and are not allergic to them.
- If you are of childbearing age, you agree to use effective birth control during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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