Stem cell injections for Crohn’s lesions that won’t heal
Treatments studied
Part of Digestive system clinical trials.
This study tests injections of stem cells placed directly into Crohn’s affected tissue. It may help people whose Crohn’s disease lesions have not responded to standard medicines and biologic therapies.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and can sign informed consent
- You have Crohn’s disease for more than 6 months
- You have at least one Crohn’s lesion that is not improving despite multiple standard treatments (including anti-TNF medicines, vedolizumab, or ustekinumab)
- Your lesion must be reachable by colonoscopy/ileocolonoscopy (for strictures/ulcers) or be an actively draining perianal fistula
- Your condition does not need urgent bowel surgery and you do not have a blockage
- You are not pregnant (and will not plan pregnancy during the next year)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This early-phase study tests whether a stem cell transplant can improve Crohn’s disease in teens and young adults whose disease is active and not responding to standard medicines. It may help some people who are not doing well despite several prior treatments, but it also involves intensive study procedures and safety checks.
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This trial tests whether a type of stem cell called HB-adMSCs can help treat Crohn's disease. It is for adults with mild to moderate Crohn's who have certain signs of inflammation in their blood and recent imaging of their condition.
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