Before-surgery immunotherapy for MSI-H or dMMR colon cancer
Part of Cancer, Digestive system clinical trials.
This trial studies a treatment given before surgery using toripalimab, with or without celecoxib, for colon or rectal cancer that has MSI-H or dMMR tumor features. It aims to shrink or control the cancer before the operation and compare whether adding celecoxib helps.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You can sign an informed consent form to join the study.
- Your colon or rectal cancer tests show either dMMR or MSI-H results (from tumor tissue).
- Your cancer is locally advanced (often involves nearby lymph nodes) and has not spread to distant organs.
- You have not had any prior medicines to treat colorectal cancer, like chemotherapy or immunotherapy.
- You’re age 18–75 and in generally good condition (ECOG 0 or 1).
- You can’t have bowel obstruction, perforation, or uncontrolled bleeding from the main tumor.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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