Combination therapy before surgery for rectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of radiation, two immunotherapy drugs (iparomlimab and tuvonralimab), a targeted therapy (regorafenib), and chemotherapy (CAPOX) given before surgery for locally advanced rectal cancer. The goal is to see if this approach can shrink the tumor and improve outcomes for people whose tumors have normal mismatch repair proteins (pMMR/MSS).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have a type of rectal cancer called adenocarcinoma, and the tumor is within about 5 inches (12 cm) of the anal opening.
- Your cancer is at stage cT3-4aN0M0 or cT1-4aN+M0 (meaning it has grown through the rectal wall or spread to nearby lymph nodes but not to distant organs).
- Your tumor is pMMR or MSS (a lab test shows normal mismatch repair proteins).
- You have not had any previous treatment for this rectal cancer, such as radiation, chemotherapy, or surgery.
- You are healthy enough for routine activities (ECOG 0 or 1), your organs work well, and you are willing to have surgery after the medicines.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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