Toripalimab plus celecoxib for dMMR/MSI-H colorectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests whether combining toripalimab (an immunotherapy) with celecoxib (an anti-inflammatory drug) can shrink locally advanced colorectal tumors that have specific genetic features (dMMR or MSI-H). It aims to help people who haven't had any prior treatment for their colorectal cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have colorectal cancer that has spread to nearby tissues or lymph nodes but not to other organs.
- Your tumor has a genetic feature called dMMR or MSI-H (a lab test will confirm this).
- You have not had any previous treatment for colorectal cancer (like surgery, chemotherapy, or radiation).
- You are 18 or older and in generally good health (able to do daily activities without much help).
- You do not have other active cancers, serious heart or blood vessel problems, or an autoimmune disease requiring treatment.
- You are willing to use birth control during and for 3 months after the study if applicable.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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