Hyperbaric oxygen plus donor stem cell transplant for blood cancers
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This early-phase trial studies whether breathing pure oxygen in a pressurized chamber, along with a donor stem cell transplant, can improve outcomes for certain blood cancers. It may help by supporting the body during transplant and recovery, but it is still being tested for safety and effectiveness.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 to 75 years old and able to sign consent
- Have one of these blood conditions: AML or MDS (cohort 1), or CMML, aCML, CML, CNL, myelofibrosis, or MDS/MPN overlap (cohort 2)
- Be well enough for transplant (Karnofsky score 70% or higher, and heart/lung limits that meet study cutoffs)
- Have heart tests okay for transplant (heart pumping strength at least 45% and no serious rhythm problem) and lung tests at least 50% of predicted
- Women who could become pregnant and men/partners who could become pregnant must use reliable birth control during the study and for 30 days after, with a recent negative pregnancy test
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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