Biologic shot to prevent knee arthritis after ACL injury
Treatments studied
Part of Bones, joints & muscles, Injuries & trauma clinical trials.
This early-phase trial tests a biologic medicine (anakinra) given after an ACL injury to try to prevent or reduce later osteoarthritis (wear-and-tear arthritis). It enrolls young adults who recently tore their ACL and are planning a specific type of ACL reconstruction.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 to 35 years old, and your growth plates have already closed
- Your ACL tear was confirmed by MRI within 2 weeks of when you first got evaluated
- You plan to have ACL surgery using your own kneecap tendon (bone-patellar tendon-bone graft) within 45 days of the injury
- Your knee does not involve certain other ligament injuries (no posterior cruciate ligament injury; MCL is at most mild, and no posterolateral corner injury)
- You have not had prior surgery or a prior injury in that same knee
- You do not have infection, anakinra allergy, recent cortisone shots, bleeding/clotting disorders or blood thinners, cancer, autoimmune/inflammatory disease, weak immunity, or significant kidney failure
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether adding a concentrated bone marrow injection during repeat ACL surgery helps healing and recovery better than surgery alone. If you have had a previous ACL reconstruction that failed, you may be eligible.
This trial tests if injecting platelet-rich plasma (a concentration of your own blood platelets) after ACL reconstruction helps with healing and reduces pain. It's for people who recently had ACL surgery and want to try an extra treatment to improve recovery.
This trial tests whether a shot of your own concentrated platelets (PRP) into the knee improves healing after a recent ACL injury. It's for people with mild to moderate ACL tears and no major other knee damage.
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This trial tests a surgical procedure that replaces a damaged meniscus (the knee's cushion) while also repairing the ACL (a key ligament), using a tendon graft to stabilize the knee. It is designed for people whose knee problems have not gotten better with therapy or pain relievers.
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