Second stem cell transplant for sickle cell with declining donor cells
Part of Blood & lymphatic clinical trials.
This Phase 1/2 study tests whether repeating a stem cell transplant can help people with sickle cell disease (SCD) whose donor cells are no longer holding strong. It may help restore healthier blood cell production and reduce symptoms such as pain crises and severe anemia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have sickle cell disease (SCD) or beta thalassemia and previously had a stem cell transplant from a matched donor (allogeneic HSCT).
- After the first transplant, donor cells are still present but are gradually dropping (persistent donor chimerism).
- You have ongoing/recurrent disease symptoms (for SCD, SCD blood marker is at or above the study threshold, or your symptoms are clearly coming back).
- You (the patient) are at least 4 years old.
- Your heart function tests are adequate: ejection fraction at least 35% (DLCO may be skipped for some younger children).
- You are not pregnant or breastfeeding, and you don’t have a recent uncontrolled serious infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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