Stem cell transplant for blood and immune diseases
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial uses a special type of stem cell transplant that removes certain cells to reduce complications. It may help people with blood diseases, immune problems, or other conditions that can be treated with a stem cell transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a disease that can be treated with a stem cell transplant, such as sickle cell disease, leukemia, or a bone marrow failure syndrome.
- You do not have a suitable fully matched sibling donor, unless there are special reasons a different donor is safer.
- You have a donor who is either a close relative with a partial match or an unrelated donor with a specific tissue type match.
- You are not pregnant, and if you could become pregnant, you must have a negative pregnancy test.
- If you are having a first or planned transplant, you need to be in generally good health with a performance score of at least 60%.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This expanded-access study offers a specific type of stem cell transplant preparation that removes certain immune cells (CD3 and CD19) from donor stem cells. It is for children who need a transplant but do not have a fully matched sibling donor and whose team cannot use the hospital’s usual matching device protocol.
This trial tests a special immune-cell “preparation” treatment (called T-cell and B-cell depletion) with adjusted anti-thymocyte globulin (ATG) dosing before a stem cell transplant. It aims to reduce immune-related transplant complications in people under 25 with certain blood cancers in a specific remission status.
This trial tests a new approach for people with non-cancerous blood and immune system diseases. It uses your own engineered immune cells (CAR-T cells) to prepare your body for a stem cell transplant from a relative.
This trial tests a specialized donor stem cell transplant to treat high-risk problems in the blood and bone marrow, including some cancers and non-cancers. It may help by using donor immune cells designed to better control the disease after transplant.
This trial tests a type of stem cell transplant that removes certain immune cells (alpha-beta T cells and CD19 B cells) from the donor cells. This may help prevent graft-versus-host disease and other complications in patients with blood cancers who do not have a matched sibling donor.
This trial studies a type of stem cell transplant (bone marrow transplant) that uses a donor who is only half-matched to the patient, often a parent or sibling. It is for children and young adults with certain blood diseases, including sickle cell disease, thalassemia, bone marrow failure, and immune disorders. The transplant aims to replace the diseased blood-forming cells with healthy ones from the donor.
Hear when a new Leukemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.