Single injection treatment for chronic low back disc pain
Part of Bones, joints & muscles, Pain clinical trials.
This Phase 2 study tests whether one injection of BRTX 100 can reduce pain and improve function in people with chronic, disc-related low back pain. It looks for whether the treatment is safe and works better than what you’ve already tried.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have low back pain for at least 6 months that worsens with sitting, bending forward, lifting, twisting, coughing, sneezing, or straining
- You tried at least 6 months of non-surgery care (like rest, anti-inflammatories/pain medicines, injections, massage/physical therapy/chiropractic) but it didn’t help enough
- Your current pain and disability scores fit the study limits (pain on a 0–100 scale between 40 and 80, and disability score between 30 and 89)
- Your MRI shows degenerative disc disease at the pain level, with specific scoring rules, and disc height is preserved (at least 50%)
- No major structural problems on MRI (no severe narrowing, no disc pieces that are out of place, and no significant spine deformity or instability)
- You can’t be pregnant/breastfeeding, and you must use highly effective birth control if you could become pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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