RH-matched blood transfusions for sickle cell patients
Part of Blood & lymphatic clinical trials.
This study tests whether giving red blood cells matched to your child’s RH (a blood marker) can improve safety and fit for people with sickle cell disease who need regular transfusions. It may help reduce mismatches by using blood units selected to match the child’s blood type more closely.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child must be older than 6 months
- Your child has sickle cell disease (SCD), any RH or other genotype
- Your child is expected to need chronic red blood cell transfusions for a period of time
- A parent/guardian can give consent, and the child can agree if they are old enough
- There must be enough RH-matched red blood cell units available for your child’s rare blood marker pattern
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a way to do a bone marrow (stem cell) transplant from an HLA-matched sibling in children with sickle cell disease, aiming to lower the risk of serious side effects. You may be considered if you have certain past sickle complications and your body can safely handle the transplant plan.
This study looks at whether certain genes make people with sickle cell disease more likely to develop an immune reaction to blood transfusions. It aims to help doctors predict transfusion risks and improve care.
This trial is testing a new, gentler type of bone marrow transplant for children and young adults with sickle cell disease who have a healthy sibling donor with a mismatched blood type or who have antibodies against their donor's red blood cells. The goal is to replace the faulty bone marrow with healthy donor cells, with fewer side effects than traditional transplants.
This trial tests a radioactive antibody (131I-apamistamab) as part of conditioning before a stem cell transplant from a matched sibling donor. It aims to make the transplant safer and more effective for people with severe sickle cell disease.
This early-phase study tests whether a “half-matched” donor bone marrow transplant, with special medicines to calm the immune system before transplant, can improve outcomes for people with sickle cell disease. It may help high-risk patients who have frequent complications and don’t have a fully matched donor.
This trial tests a special type of red blood cell transfusion that holds less oxygen. It may help people with sickle cell anemia who already get regular transfusions.
Hear when a new Sickle Cells Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.