Burosumab and vitamin D for kids needing skull surgery
Part of Bones, joints & muscles, Genetic & congenital clinical trials.
This study tests whether burosumab and vitamin D affect bone cells before and around the time of craniosynostosis surgery in children. It may help researchers understand treatment options for rare calcium and phosphate bone disorders that can affect skull growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child must be between 4 months and 18 years old
- Your child needs surgery for craniosynostosis (early skull suture closure) and is being followed by rare bone/calcium/phosphate centers
- You (and your child, with your parent/guardian permission) must agree to join the study
- Your child must not be taking oral corticosteroids right now
- Your child must not have used corticosteroids for more than 3 months before the surgery
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new medical device that helps guide surgery for children with certain skull conditions (trigonocephaly or anterior plagiocephaly). The device is designed to make the surgery safer and more precise for children aged 4 to 24 months.
This study tests a new treatment called ASO (antisense oligonucleotide) therapy on tissue samples from babies with syndromic craniosynostosis—a condition where skull bones fuse too early due to specific genetic changes. Researchers hope this approach could eventually help prevent or reduce the severity of this condition.
This research study examines the bone structure and healing of the skull in babies with craniosynostosis (when skull bones fuse too early). Researchers will analyze bone samples to better understand how the condition affects bone development and strength.
This study is building a database of medical information and images from children with certain conditions affecting the face and skull, such as craniosynostosis, achondroplasia, and osteogenesis imperfecta. The goal is to better understand these conditions and improve future care.
This study checks if a special monitor (called Pleth Variability Index) helps doctors manage fluids better during surgery for children with craniosynostosis. It may lead to safer recovery for your child.
This study looks at how general anesthesia may affect “brain injury marker” levels during and after surgery for single-suture craniosynostosis in infants. It may help doctors better understand anesthesia timing and safety for babies having corrective surgery.
Hear when a new Craniosynostoses trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.