Laser surgery plus targeted radiation for recurrent brain gliomas
Part of Brain & nervous system, Cancer clinical trials.
This trial studies whether a special laser procedure (LITT) followed by focused, reduced-dose radiation can control glioma tumors that have come back. It may help people with recurrent brain tumors avoid or delay more extensive treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a history of glioma (WHO grade 2–4) that is showing signs of coming back on MRI
- You have had radiation before, and you have not already had re-irradiation (extra radiation) for this recurrence
- Your MRI shows a tumor that enhances (shows contrast uptake) and is 6 cm or smaller at its widest point
- You can have a minimally invasive laser/biopsy procedure—your doctors think it is technically possible and safe
- You are at least 22 years old and can do MRI scans (you do not have a medical reason you cannot get an MRI)
- Your overall functioning is good enough for treatment (Karnofsky score of 60% or higher)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial studies a two-step treatment for newly diagnosed high-grade glioma: first laser treatment (LITT) to target the tumor, followed by a shorter, more focused course of radiation. It may help shrink or control the tumor while limiting treatment time.
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This study tests a light-activated therapy (radiodynamic therapy) using a special medicine to help treat a brain tumor that has come back after prior treatment. It may be offered after doctors decide you need further radiation for your recurrence.
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