Treatment
Acetaminophen clinical trials
We’re tracking 65 recruiting studies that include Acetaminophen, each written for real people, not researchers, below.
Recruiting studies
- NCT07759349RecruitingEarly Phase 1
Pain relief choices after root canal treatment
This study compares three different pain relievers to see which works best for pain after a single-visit root canal. It may help find better ways to manage post-procedure discomfort.
Karachi, SindhAges 18–60 - NCT05425355RecruitingPhase 4
IV versus oral acetaminophen after hip-fracture surgery
This trial compares giving acetaminophen (Tylenol) through a vein versus by mouth after hip-fracture surgery. It may help find which method works better for pain control and recovery in adults.
Toronto, OntarioAges 60 years+ - NCT03825809RecruitingPhase 2/Phase 3
Non-narcotic pain medicine after labral shoulder surgery
This trial studies whether a non-narcotic pain plan after labral (shoulder) surgery can control pain as well as or better than usual treatment. It may help patients avoid opioid (narcotic) pain medicines after surgery.
Detroit, MichiganAges 18 years+ - NCT05722782RecruitingPhase 2
Kidney stone pain treatment after ER discharge
This study compares an anti-inflammatory pain medicine (NSAID) given by mouth versus acetaminophen (paracetamol) or placebo after you leave the emergency room for a “renal colic” (kidney stone pain). It looks at whether the NSAID helps control pain better and whether it’s safe for people with uncomplicated kidney stone pain.
MonastirAges 18 years+ - NCT06613178RecruitingPhase 4
IV acetaminophen for heart surgery recovery
This trial tests if giving acetaminophen (Tylenol) through a vein after heart surgery can help patients recover better. You may be a good fit if you are having planned heart surgery that is not an emergency.
Vancouver, British ColumbiaAges 18 years+ - NCT07709598RecruitingPhase 2/Phase 3
HL-1186 for pain after abdominal surgery
This study tests a new painkiller called HL-1186 for people having abdominal surgery. If you qualify and enroll, you will receive the drug after surgery to see if it safely helps reduce your pain better than a placebo (a pill with no medicine).
Chengdu, SichuanAges 18–75 - NCT07699601RecruitingPhase 2/Phase 3
Testing a pain tablet after orthopedic surgery
This trial tests an investigational tablet called HL-1186 for controlling pain after orthopedic surgery. It explores whether the drug can safely reduce moderate to severe pain when given after the procedure.
Changsha, HunanAges 18–75 - NCT07620665Recruiting
Pain Relief Medicine for Gallbladder Removal Surgery
This trial tests a new pain medication called opiranserin for patients having minimally invasive gallbladder surgery (a small-cut procedure). The goal is to see if it safely reduces pain after surgery.
SeoulAges 19 years+ - NCT07525219RecruitingPhase 3
Pain Relief During Stereotactic Head Frame Placement
This study compares a new pain medication called suzetrigine with acetaminophen (Tylenol) for patients who need a stereotactic head frame placed as part of their scheduled medical procedure. The frame holds your head still during brain imaging or treatment.
Winston-Salem, North CarolinaAges 21 years+ - NCT07400471RecruitingEarly Phase 1
Pain relief before root canal: a medicine combination
This trial tests whether a combination of pain medicines given before a root canal can lower pain afterward. It is for people who have moderate to severe tooth pain and are healthy enough for standard treatment.
Chittagong, ChattogramAges 18 years+ - NCT07368738Enrolling by invitationPhase 4
IV Pain Meds for Shock Wave Lithotripsy
This study tests whether giving two pain relievers—acetaminophen (Tylenol) and ketorolac (an anti-inflammatory)—through an IV during shock wave lithotripsy helps control pain better than standard care. You may qualify if you need this kidney stone procedure and don't have certain health conditions.
Saint John, New BrunswickAges 19 years+ - NCT06479122RecruitingPhase 4
Pain relief after C-section: acetaminophen with or without ibuprofen
This study compares two common pain relievers after C-section: acetaminophen alone versus acetaminophen plus ibuprofen. It aims to see if the combination offers better pain control after childbirth.
SeoulAges 19 years+ - NCT05878015Enrolling by invitationPhase 4
IV acetaminophen for small bowel blockage symptoms
This Phase 4 study tests whether giving acetaminophen through a vein helps people with a small bowel obstruction (a blockage in the intestines) that is causing abdominal pain. It’s looking for a benefit in pain control and how people do during treatment.
Jacksonville, FloridaAges 18 years+ - NCT05340582RecruitingPhase 2
Ibuprofen plus acetaminophen for a heart condition in very premature babies
This Phase 2 study tests whether giving ibuprofen together with acetaminophen improves outcomes for an important heart connection (PDA) in extremely premature infants. It compares how this medicine approach affects the baby’s heart-related measurements and short-term progress.
Newcastle, New South WalesAges Up to 6 months - NCT03823534RecruitingPhase 3
Study pain control after preventive femur bone surgery
This Phase 3 study tests a pain medicine plan used after preventive surgery to place a metal rod inside the thigh bone (femur) before a fracture happens. The goal is to find an approach that controls post-surgery pain while being safe for the right patients.
St Louis, MissouriAges 18 years+ - NCT07785609RecruitingPhase 2
New drug combination for advanced solid tumors
This trial tests a new drug combination for people with advanced solid tumors. It aims to see if the combination is safe and may shrink tumors.
San Antonio, TexasAges 18 years+ - NCT06997016Enrolling by invitationPhase 4
Recovery program for living donor kidney transplant
This trial tests a special recovery program (ERAS) for people who get a kidney from a living donor. The program aims to help you heal faster and feel better after surgery.
Fort Worth, TexasAges 18 years+ - NCT05557448RecruitingPhase 2
N-Acetylcysteine treatment for serious acetaminophen overdose
This Phase 2 trial studies whether TYNADOTE® can treat people who have taken a harmful acetaminophen (Tylenol) overdose while checking safety. It may be considered if your overdose is high enough to put you at risk for liver injury and you can follow the treatment and follow-up visits.
Taipei, Beitou DistrictAges 20 years+ - NCT07840183RecruitingPhase 4
Epidural versus other pain relief for open ventral hernia repair
This study compares two ways to manage pain after hernia repair surgery: using an epidural (a small tube in your back that delivers pain medicine) versus other pain medications that aim to reduce opioid use. The goal is to see which method provides better pain relief and helps you recover more comfortably.
Chicago, IllinoisAges 18–80 - NCT07824258RecruitingPhase 1
Pain relief study after vasectomy
This study tests whether a pain-relief method helps reduce discomfort after a vasectomy. It may help you recover more comfortably.
New York, New YorkAges 18–65 - NCT07803744RecruitingPhase 1
Study of tirzepatide for type 1 diabetes with overweight
This study tests a weekly injection called tirzepatide in people with type 1 diabetes who are overweight or have obesity. The goal is to see if it helps with blood sugar control and weight loss when added to insulin therapy.
Miami, FloridaAges 18–70 - NCT07765823Recruiting
N-acetylcysteine for liver failure not caused by acetaminophen
This trial tests whether the drug N-acetylcysteine (NAC) can help people with sudden liver failure that is not caused by acetaminophen (like Tylenol). If you qualify, you may receive NAC, which might help your liver recover.
Lahore, Punjab ProvinceAges 18–60 - NCT07750639Enrolling by invitationPhase 4
Reducing painkiller use after hand surgery
This study tests a new approach to prescribing fewer opioid pain pills after hand, wrist, or elbow surgery. It aims to help reduce the risk of opioid misuse while still controlling pain after surgery.
Orlando, FloridaAges 18 years+ - NCT05919745RecruitingPhase 4
Ibuprofen before mouth surgery to reduce pain sensing
This trial studies whether taking ibuprofen before tooth extraction and bone graft surgery can lower how much pain you feel afterward. It may help by changing the body’s pain response during healing.
Milwaukee, WisconsinAges 18 years+
What Acetaminophen is being studied for
Conditions with recruiting Acetaminophen studies.
Common questions
- Are there clinical trials studying Acetaminophen?
- Yes. Clin2 currently lists 65 recruiting studies that include Acetaminophen, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Acetaminophen trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Acetaminophen an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Acetaminophen or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.