Noninvasive vagus nerve stimulation for stubborn spinal arthritis
Part of Bones, joints & muscles clinical trials.
This trial tests whether a noninvasive device that stimulates the vagus nerve can reduce symptoms in people with axial spondyloarthritis that hasn’t improved enough with standard medicines and biologic drugs. It may help lower pain and disease activity for those with “treatment-resistant” disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18 and 90 years old
- Have axial spondyloarthritis (as defined by ASAS) and been followed for at least 1 year
- Have active disease: BASDAI score of 4 or higher and overall pain score of 4 or higher at the start
- Have tried usual medicines and still have symptoms despite 6+ months of optimized treatment (including at least 2 NSAIDs, plus at least two biologic/biotherapy options or stopping due to side effects or intolerance)
- Be able and willing to attend weekly study visits and sign informed consent
- Not have certain health or situation issues, like pregnancy/breastfeeding, prior vagus nerve stimulation, or certain heart or ear conditions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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