Clin2
NCT04294927Possibly a fitRecruiting

Tube removal first, then ovaries later for high-risk women

BRCA1 Gene MutationBRCA2 Gene MutationRAD51C Gene MutationRAD51D Gene MutationBRIP1 Gene MutationOvarian Cancer

Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.

This study looks at whether removing the fallopian tubes first, and the ovaries later, is safe for women with certain inherited gene mutations that raise ovarian cancer risk. It may help you understand a prevention approach when you’re considered high risk and have finished having children.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
3,000 people
Ages
25 years to 50 years
Study type
Interventional

Who can take part

  • You have a high-risk inherited gene change: BRCA1, BRCA2, RAD51C, RAD51D, or BRIP1
  • Your age fits the study range for your specific gene (about mid-20s to mid-40s, depending on which gene)
  • You have finished having children and agree to follow the study steps
  • You still have at least one fallopian tube
  • You have not had both fallopian tubes removed already (no prior removal of both tubes)

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05287451Recruiting
Tube removal now, ovaries later for high cancer-risk women

This study looks at the safety of removing your fallopian tubes first (RRS) and delaying ovary removal (oophorectomy) to lower cancer risk. It focuses on women who carry certain inherited gene changes, and may help avoid earlier menopause for some people.

Chicago, Illinois
NCT00005095Recruiting
Ovarian cancer risk study: specimens and health data

This study collects tissue samples and medical information from people at higher risk for ovarian cancer or undergoing gynecologic surgery. Researchers use this data to develop better ways to detect and prevent ovarian cancer early.

Chicago, Illinois
NCT07532434Recruiting
Risk-Reducing Surgery for Hereditary Ovarian Cancer

This study follows women who carry gene mutations that increase ovarian cancer risk to understand how preventive surgery affects their health, quality of life, and peace of mind. Researchers will track your outcomes over 3 years to help inform future treatment decisions for others at similar risk.

Beijing, Beijing Municipality
NCT07761416Not yet recruiting· Early Phase 1
Removing fallopian tubes during weight-loss surgery to prevent ovarian cancer

This study looks at whether removing the fallopian tubes at the same time as weight-loss surgery can help prevent ovarian cancer. If you join, during your bariatric surgery, your surgeon would also remove your fallopian tubes.

NCT05200260Recruiting· Phase 2
Surgery plus maintenance medicines for advanced ovarian cancer

This trial checks whether having surgery to remove as much tumor as possible, followed by ongoing targeted treatment, helps people with advanced ovarian (and related) cancers live longer and/or control cancer better. It specifically uses tumor-testing results to match patients and then continues treatment after surgery.

Foshan
NCT06726330Not yet recruiting
Risk-reducing choices for women with gene changes

This study looks at different ways to lower the risk of ovarian and pelvic cancer in women who have certain gene changes. It may involve removing the fallopian tubes (fimbriectomy) as a preventive step, and compares different strategies to see which works best.

Lyon, France

Hear when a new Ovarian cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.