Esketamine after breast surgery for depression and gut changes
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This trial studies whether esketamine given around the time of breast cancer surgery can improve depression and change gut bacteria. It also monitors your sleep/deep anesthesia level (with a simple monitoring number).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old and have not reached menopause
- You are scheduled for an elective (planned) breast cancer operation
- Your general health is relatively good (ASA class I to II)
- You have depression symptoms with a MADRS score of 22 or higher
- You do not have major stomach/esophagus surgery history (including partial/total gastrectomy or prior esophageal surgery)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether esketamine, an anesthetic, can help reduce severe depression symptoms in women having breast cancer surgery. You may qualify if you have severe depression before surgery.
This trial tests whether giving a medication called esketamine during breast cancer surgery can help reduce negative emotions like depression and anxiety after surgery. It is for women who already have mild to severe depression symptoms.
This trial tests whether a medicine called esketamine (given during anesthesia) can help reduce anxiety, sadness, or other negative emotions that often occur before and after breast cancer surgery. This could help you feel better emotionally during your recovery.
This study tests whether adding a low dose of esketamine (a type of anesthesia) to modified electroconvulsive therapy (ECT) helps treat severe depression in teenagers. It aims to see if this combination works better and is safer than ECT alone.
This trial tests whether a low dose of esketamine can improve sleep quality in women with breast cancer who are receiving neoadjuvant chemotherapy. If you have trouble sleeping during treatment, this study may find a new way to help.
This trial tests if a low dose of esketamine, given during anesthesia, can improve sleep quality after lower-limb fracture surgery in postmenopausal women. It aims to find a safe way to help you rest better after your operation.
Hear when a new Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.