Whole-body radiation plus chemo before stem cell transplant
Treatments studied
Part of Skin clinical trials.
This early-stage trial studies whether giving whole-body radiation and a chemotherapy medicine before an autologous stem cell transplant can improve severe systemic sclerosis. It aims to reset the immune system, but it requires careful safety checks and close follow-up.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe systemic sclerosis and were assessed within 30 days before transplant conditioning starts
- You are healthy enough for the study (Karnofsky performance status 70 or higher)
- Your transplant team says you are a candidate for this specific pre-transplant plan: whole-body radiation plus cyclophosphamide
- Your organs are strong enough for a stem cell transplant based on your blood/heart/lung/kidney (as judged by your hematologist)
- If you could become pregnant (or you are male), you must use reliable birth control during the study and for 6 months after
- You can understand the plan and are willing to sign informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a risk-adapted conditioning regimen (chemotherapy and/or radiation given before transplant) for people with certain blood cancers or bone marrow disorders who need a stem cell transplant from a donor. The goal is to tailor the conditioning strength to each patient’s risk, which may help improve outcomes and reduce side effects.
This Phase 2 study tests whether an “autologous” stem cell transplant—using your own stem cells—can reduce systemic sclerosis disease activity. It is mainly for children, teens, and young adults whose disease did not improve despite standard medicines.
This trial tests using targeted radiation therapy right before a stem cell transplant from a donor, to treat blood cancers that have spread outside the bone marrow. It aims to see if this approach is safe and can help the transplant work better.
This trial tests a combination of total body irradiation and two chemotherapy drugs as preparation for a second stem cell transplant in people with blood cancers that relapsed or didn't respond to the first transplant.
This trial tests a precise type of radiation called intensity modulated total marrow irradiation before a stem cell transplant. It aims to destroy cancer cells while reducing side effects for patients with high-risk leukemia or myelodysplastic syndrome.
This trial tests a new type of radiation therapy called automated total marrow and lymphoid irradiation (TMLI) given before a stem cell transplant. It's designed to treat blood cancers like leukemia and myelodysplastic syndrome by destroying cancer cells and preparing the body to accept donor stem cells.
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