Study of ALS and related genetic nerve disorders using scans and fluid tests
Part of Brain & nervous system clinical trials.
This study looks at signs and biology (biomarkers) in people with certain inherited nerve conditions caused by RNA-processing gene changes. It may help researchers understand disease patterns and measure health changes using MRI scans and sometimes a spinal fluid test.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 5 or older.
- You have a confirmed genetic change linked to ALS4 or another RNA-processing-related neurological condition (or you’re an unaffected family member with a family history).
- If you’re having genetic testing or screening, it must match specific gene names such as SETX, RNaseH1, or RNaseH2 (or a related RNA-processing defect).
- You can communicate with the study team and follow study instructions, and you (or your child) can agree to join the study.
- For healthy controls: you either have a close family relative with an RNA-processing gene change, or you are an unrelated healthy person with no neuromuscular diagnosis.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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