Brain stimulation for treatment-resistant depression and chronic pain
Part of Mental health, Pain clinical trials.
This study tests a non-invasive brain stimulation treatment, called transcranial magnetic stimulation (TMS), to see if it can help people who have both major depression that hasn't improved with medication and chronic pain from fibromyalgia or chronic fatigue syndrome. It aims to reduce both depression and pain symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You must speak English fluently.
- You must have a diagnosis of moderate or severe major depression, with a score of at least 17 on a standard depression scale.
- You must have tried at least two different antidepressant medications from different classes without success.
- You must have tried at least two evidence-based add-on treatments (like therapy or other medications) for depression, and had a trial of effective psychotherapy.
- You must also have a confirmed diagnosis of fibromyalgia or chronic fatigue syndrome, with moderate pain lasting at least 3 months.
- You cannot have had prior TMS treatment, be pregnant, have active suicidal thoughts, or have certain medical conditions (like epilepsy or metal implants).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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