Lower blood pressure to study outcomes in mild valve narrowing
Part of Heart & circulation clinical trials.
This trial studies whether lowering blood pressure affects health outcomes in people who have valve narrowing in the heart but no valve symptoms yet. It may help you understand which blood pressure targets are safest when the aortic valve is not fully opening.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult (over 18 years old)
- Your heart scan shows mild-to-moderate aortic valve narrowing (Vmax 3.0–5.0 m/s and/or valve area ≤ 1.2 cm²)
- You currently have blood pressure with systolic (top number) at least 127 mmHg
- Your pumping strength is preserved (left ventricular ejection fraction at least 50%)
- If you can become pregnant: you can use reliable birth control and have a negative pregnancy test
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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