Study heart function and frailty in people with aortic valve narrowing
Part of Heart & circulation clinical trials.
This study looks at how heart mechanics, blood markers, and frailty relate to symptoms and heart measurements in people with aortic stenosis (a stiff, narrowed heart valve). It may help doctors better understand who is at higher risk and how disease changes over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 years or older
- If you’re in the patient group: have aortic stenosis by an ultrasound (Doppler echo) with one of these categories: moderate, severe, or “heart failure with preserved pumping strength” (LVEF 45% or higher)
- If you’re in the healthy control group: be generally healthy and able to follow screening requirements
- Have not had valve replacement surgery or a transcatheter valve procedure before
- Not have certain recent major events (like heart attack in the last 3 months or stroke/TIA in the last 6 months)
- Be able to do a 6-minute walk test (6MWTD) and not have conditions that would prevent it
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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