Tested blood pressure pills for mild to moderate aortic narrowing
Treatments studied
Part of Heart & circulation clinical trials.
This study tests whether angiotensin receptor blocker (ARB) blood pressure medication helps people with mild to moderate aortic stenosis (a narrowing of the heart’s main valve). It looks at safety and whether the treatment offers benefit for your heart and blood flow.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have mild to moderate aortic stenosis based on an echo test (jet speed between 2.5 and under 4 m/s)
- Your heart’s pumping strength is normal (left ventricular ejection fraction at least 50%)
- Your blood pressure is above set minimums (systolic over 110 and diastolic over 70)
- You do not have more-than-mild leaks in the aortic or mitral valves, and you do not have mitral stenosis
- You can take (and are not allergic to) ARB-type medications, and you are not already required to take similar “renin-angiotensin” medicines or aliskiren
- You have kidney and liver health that is not severely reduced, and you are not pregnant or unable to consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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