Preemptive drug DEC-C after transplant to reduce hidden cancer
Part of Blood & lymphatic clinical trials.
This trial tests whether giving DEC-C (a decitabine-based treatment) soon after an allogeneic transplant can improve outcomes for MDS patients who still have “measurable residual disease” (hidden leftover disease) detectable by a genetic test. It also compares this approach to standard observation if the hidden disease is not detected or if the higher-risk safety checks are not met.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have MDS and had an allogeneic stem cell transplant (from a donor).
- You’re between 18 and 75 years old.
- Before transplant, you had gene-panel testing, and it found mutations that the trial’s test can track.
- At about Day 30 after transplant, you must have a plan to follow the study’s treatment assignment (DEC-C if eligible, or observation if not).
- You must be well enough and have blood counts and organ function that meet the study safety thresholds for the DEC-C arm.
- If you could become pregnant, you must use reliable birth control (and not be pregnant or breastfeeding).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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