Botox-like injection study for arm spasticity after stroke
Part of Bones, joints & muscles, Brain & nervous system, Injuries & trauma clinical trials.
This trial tests whether IPN10200, a Botox-like treatment, is safe and helps reduce stiff, tight upper-arm muscles caused by spasticity after stroke or brain injury. You may be able to join if you meet specific timing, prior-treatment, and muscle-stiffness measurements.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18–70 years old (for dose escalation, 18–65) when you sign consent
- Have spastic weakness on one side of your body after stroke or traumatic brain injury, at least 6 months ago
- Not have received botulinum toxin injections (BoNT) recently (or never had them), with the last injection at least 4 months before baseline
- Have specific stiffness measurements in the target arm/muscles (MAS score at least 2 and angle of spasticity at least 5°)
- No fixed joint contractures (for example, wrist/elbow/finger can’t fully extend in a set way)
- Keep therapies steady (physiotherapy/occupational therapy/splints/related meds like benzodiazepines or muscle relaxants) starting 30 days before baseline through Month 3, and as directed after
- Use reliable birth control rules if pregnancy is possible, and agree to follow them for the whole study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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