Clinical trials
Spasticity clinical trials
Below are recruiting spasticity clinical trials, each written for real people, not researchers. We’re tracking 154 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT06553976Recruiting
Research network for hereditary spastic paraplegia
This trial aims to build a research network and gather information from people with two genetic types of hereditary spastic paraplegia (SPG4 and SPG5A). It will help doctors better understand these conditions and improve care.
Miami, FloridaAges Any age - NCT06261424Recruiting
Exercise program for spastic ataxia types ARSACS and SPG7
This study tests whether a supervised exercise program (including pool exercises) can help people with certain types of hereditary ataxia. The goal is to see if it reduces symptoms like muscle stiffness and coordination problems.
Baie-Saint-Paul, QuebecAges 16 years+ - NCT04712812Recruiting
Study of childhood-onset hereditary spastic paraplegia
This study follows people with hereditary spastic paraplegia that started in childhood to better understand how the condition progresses over time. It may help doctors learn what to expect and how to plan care, using genetic information and family history.
Boston, MassachusettsAges Up to 30 years - NCT06070233Recruiting
Radiosurgery for spasticity after stroke or injury
This trial tests a non-invasive radiation treatment (radiosurgery) to reduce severe muscle stiffness (spasticity) that hasn't improved with other treatments. It may help people with spasticity caused by stroke, spinal cord injury, or cerebral palsy.
Winter Park, FloridaAges 16 years+ - NCT06902168Recruiting
Diving and pool exercises for muscle tightness in kids with cerebral palsy
This study tests whether diving and swimming-type exercises can help reduce muscle stiffness and improve movement in young children with spastic cerebral palsy. It is for children ages 2 to 5 who have significant mobility challenges (GMFCS levels IV or V).
Banhā, BenhaAges 2–5 - NCT07488429Recruiting
Brain stimulation plus therapy for leg function in cerebral palsy
This study tests whether combining a gentle brain stimulation treatment (rTMS) with physical therapy can help improve leg movement and reduce muscle stiffness in children with cerebral palsy. The goal is to see if this combination works better than therapy alone.
AnkaraAges 5–18 - NCT07007858Enrolling by invitation
Stretch therapy for leg stiffness in kids with CP
This trial tests if a fast, gentle stretching technique can reduce leg stiffness and improve walking in children with cerebral palsy (CP). It may be an option for children who are already planning to receive Botox injections for tight calf muscles.
Kayseri, TurkeyAges 2–8 - NCT03402854Recruiting
Brain stimulation plus arm therapy for children with one-sided CP
This study tests whether a non-painful brain stimulation treatment plus bimanual (two-hand) arm therapy can improve arm and hand use in children with congenital hemiplegic cerebral palsy. It may help children strengthen and control the affected hand and improve daily movement.
White Plains, New YorkAges 6–18 - NCT05354622Recruiting
Genetic testing study for inherited leg stiffness
This study looks at genes (DNA) to understand an inherited condition that causes gradually worsening leg stiffness. It may help researchers learn what causes the condition and potentially guide future care.
Boston, MassachusettsAges 1 month–30 years - NCT06767631Recruiting
Muscle and nerve changes after botox for stroke foot tightness
This study looks at how botulinum toxin (botox) injections affect the muscles, tendons, and nerves in the lower leg of people who have had a stroke and have a tight, twisted foot (equinovarus). It aims to understand these changes to improve future treatments.
LeuvenAges 40–60 - NCT06782464Recruiting
Freezing nerves for shoulder pain after stroke or brain injury
This trial tests if freezing certain nerves in the upper arm (cryoneurolysis) works as well as standard care for reducing shoulder pain and muscle tightness after a stroke or brain injury. It aims to improve function and ease caregiving tasks.
LuxembourgAges 18 years+ - NCT07118228Recruiting
Ultrasound study of muscle in children with spastic cerebral palsy
This study uses ultrasound to look at muscle shape and function in children with spastic cerebral palsy. It aims to see how these muscle features relate to movement abilities, which could help guide future treatments.
KocaeliAges 4–18 - NCT07433647Recruiting
Brain MRI changes in adults with cerebral palsy
This study looks at how the brain changes over time in people with cerebral palsy by reviewing MRI scans done as part of their regular care. It aims to understand brain health in adults with cerebral palsy.
New York, New YorkAges 18–80 - NCT07466823Recruiting
Spasticity Patterns and Quality of Life in MS
This study looks at patterns of muscle stiffness (spasticity) in people with multiple sclerosis and how these patterns affect daily life and well-being. It aims to better understand the link between spasticity and quality of life.
IstanbulAges 18 years+ - NCT06696040Enrolling by invitation
Kinesiotherapy machine for leg stiffness and walking in neurological patients
This trial tests if a passive kinesiotherapy machine can improve leg stiffness (spasticity) and walking ability in people with neurological conditions like stroke or cerebral palsy. It may help those who have trouble moving their legs due to tight muscles.
Caxias do Sul, Rio Grande do SulAges 9 years+ - NCT06782490RecruitingPhase 2
Testing a new drug for MS muscle stiffness
This study tests an investigational drug (BMS-986368) to see if it helps reduce muscle stiffness and spasms caused by multiple sclerosis. It may be an option if you have had spasticity for at least 6 months and are not currently using other treatments that cannot be paused.
Birmingham, AlabamaAges 18–70 - NCT05874154Recruiting
Nerve surgery vs botox for spastic foot after stroke
This trial compares two treatments—tibial nerve selective surgery and botulinum toxin (botox) injections—to improve a stiff, turning-in foot after stroke. It aims to use goal-based care to see which option works better for walking and foot function.
BronAges 18–100 - NCT06783114RecruitingPhase 2/Phase 3
Testing a new Botox-like injection for arm stiffness after stroke
This study tests an investigational botulinum toxin injection (YY001) to reduce muscle stiffness in the arm after a stroke. It may help you move your arm more easily and improve daily tasks.
Hefei, AnhuiAges 18–75 - NCT06473298Recruiting
Light tracking therapy for kids with one-sided muscle tightness
This study tests a special light-tracking activity to help children with spastic hemiplegia (tightness on one side) improve their movement. It's for kids ages 4–7 who can walk and have mild muscle tightness.
CairoAges 4–7 - NCT07478822RecruitingPhase 3
Botulinum toxin study for arm spasticity after stroke
This study tests a new botulinum toxin injection (YY001) for adults whose arm muscles are tight or stiff after a stroke. It looks at whether repeated treatments help with daily activities like washing and dressing.
BeijingAges 18–75 - NCT06958289Recruiting
Cold therapy for muscle tightness: long-term effects and brain changes
This study tests if freezing a nerve (cryoneurolysis) can reduce muscle tightness (spasticity) and improve arm movement. It also looks at how the brain may change after treatment. If you have tight muscles that improved with a numbing nerve block, you may be eligible.
London, OntarioAges 18 years+ - NCT07242300RecruitingPhase 3
Testing a new botulinum toxin for arm stiffness after stroke
This trial tests a new injectable medication (Eveotox) to see if it can safely reduce arm or hand stiffness in people who have had a stroke. The goal is to improve daily activities like dressing or cleaning your hand.
Beijing, Beijing MunicipalityAges 18–80 - NCT07747974Recruiting
Therapy for spastic cerebral palsy in children
This study compares two types of hand and arm therapy to help children with spastic cerebral palsy use their affected side better. Children will either practice with the affected hand through special exercises or use mirror therapy, which uses a mirror to create the illusion of movement.
IslamabadAges 5–9
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Common questions
- Are there clinical trials for spasticity?
- Yes. Clin2 currently lists 154 recruiting spasticity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a spasticity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a spasticity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.