Clinical trials
Spasticity clinical trials
Below are recruiting spasticity clinical trials, each written for real people, not researchers. We’re tracking 153 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT06553976Recruiting
Research network for hereditary spastic paraplegia
This trial aims to build a research network and gather information from people with two genetic types of hereditary spastic paraplegia (SPG4 and SPG5A). It will help doctors better understand these conditions and improve care.
Miami, FloridaAges Any age - NCT07488429Recruiting
Brain stimulation plus therapy for leg function in cerebral palsy
This study tests whether combining a gentle brain stimulation treatment (rTMS) with physical therapy can help improve leg movement and reduce muscle stiffness in children with cerebral palsy. The goal is to see if this combination works better than therapy alone.
AnkaraAges 5–18 - NCT06902168Recruiting
Diving and pool exercises for muscle tightness in kids with cerebral palsy
This study tests whether diving and swimming-type exercises can help reduce muscle stiffness and improve movement in young children with spastic cerebral palsy. It is for children ages 2 to 5 who have significant mobility challenges (GMFCS levels IV or V).
Banhā, BenhaAges 2–5 - NCT07007858Enrolling by invitation
Stretch therapy for leg stiffness in kids with CP
This trial tests if a fast, gentle stretching technique can reduce leg stiffness and improve walking in children with cerebral palsy (CP). It may be an option for children who are already planning to receive Botox injections for tight calf muscles.
Kayseri, TurkeyAges 2–8 - NCT06261424Recruiting
Exercise program for spastic ataxia types ARSACS and SPG7
This study tests whether a supervised exercise program (including pool exercises) can help people with certain types of hereditary ataxia. The goal is to see if it reduces symptoms like muscle stiffness and coordination problems.
Baie-Saint-Paul, QuebecAges 16 years+ - NCT06070233Recruiting
Radiosurgery for spasticity after stroke or injury
This trial tests a non-invasive radiation treatment (radiosurgery) to reduce severe muscle stiffness (spasticity) that hasn't improved with other treatments. It may help people with spasticity caused by stroke, spinal cord injury, or cerebral palsy.
Winter Park, FloridaAges 16 years+ - NCT04712812Recruiting
Study of childhood-onset hereditary spastic paraplegia
This study follows people with hereditary spastic paraplegia that started in childhood to better understand how the condition progresses over time. It may help doctors learn what to expect and how to plan care, using genetic information and family history.
Boston, MassachusettsAges Up to 30 years - NCT07798674Recruiting
Natural history study for ataxias and spastic paraplegias
This study tracks how ataxias and related movement disorders progress over time. By joining, you help researchers learn more about these conditions and prepare for future treatments.
InnsbruckAges 5 years+ - NCT07784231RecruitingPhase 1/Phase 2
Light therapy for stroke-related muscle stiffness
This study tests a light-based therapy (photobiomodulation) to see if it can help reduce muscle stiffness in people recovering from a stroke. Participants will continue their usual rehabilitation while receiving this additional treatment.
São Paulo, São PauloAges 18 years+ - NCT07466823Recruiting
Spasticity Patterns and Quality of Life in MS
This study looks at patterns of muscle stiffness (spasticity) in people with multiple sclerosis and how these patterns affect daily life and well-being. It aims to better understand the link between spasticity and quality of life.
IstanbulAges 18 years+ - NCT07433647Recruiting
Brain MRI changes in adults with cerebral palsy
This study looks at how the brain changes over time in people with cerebral palsy by reviewing MRI scans done as part of their regular care. It aims to understand brain health in adults with cerebral palsy.
New York, New YorkAges 18–80 - NCT07118228Recruiting
Ultrasound study of muscle in children with spastic cerebral palsy
This study uses ultrasound to look at muscle shape and function in children with spastic cerebral palsy. It aims to see how these muscle features relate to movement abilities, which could help guide future treatments.
KocaeliAges 4–18 - NCT06782464Recruiting
Freezing nerves for shoulder pain after stroke or brain injury
This trial tests if freezing certain nerves in the upper arm (cryoneurolysis) works as well as standard care for reducing shoulder pain and muscle tightness after a stroke or brain injury. It aims to improve function and ease caregiving tasks.
LuxembourgAges 18 years+ - NCT06767631Recruiting
Muscle and nerve changes after botox for stroke foot tightness
This study looks at how botulinum toxin (botox) injections affect the muscles, tendons, and nerves in the lower leg of people who have had a stroke and have a tight, twisted foot (equinovarus). It aims to understand these changes to improve future treatments.
LeuvenAges 40–60 - NCT06696040Enrolling by invitation
Kinesiotherapy machine for leg stiffness and walking in neurological patients
This trial tests if a passive kinesiotherapy machine can improve leg stiffness (spasticity) and walking ability in people with neurological conditions like stroke or cerebral palsy. It may help those who have trouble moving their legs due to tight muscles.
Caxias do Sul, Rio Grande do SulAges 9 years+ - NCT05354622Recruiting
Genetic testing study for inherited leg stiffness
This study looks at genes (DNA) to understand an inherited condition that causes gradually worsening leg stiffness. It may help researchers learn what causes the condition and potentially guide future care.
Boston, MassachusettsAges 1 month–30 years - NCT03981276Recruiting
Study aims to understand inherited walking stiffness disorders
This study looks at the causes and biology (“biomarkers”) of hereditary spastic paraplegias and related conditions. You may join as someone with the condition, a family member without symptoms, or a healthy person, to help researchers understand what’s happening in the nervous system.
InnsbruckAges Any age - NCT04006418Recruiting
Study of spastic paraplegia in patients and healthy controls
This study enrolls people diagnosed with spastic paraplegia and also compares them with healthy people. It helps researchers learn more about the condition and may guide future care or treatments.
FuzhouAges Any age - NCT03206190Recruiting
Study for early SPG4 symptoms in family members
This study looks at people in families with a known SPG4 gene change (a SPAST mutation) to understand early, subtle signs and the beginning of symptoms. It may help researchers find better ways to detect SPG4 earlier, before full walking problems start.
TübingenAges 18–70 - NCT07829796Recruiting
Brain stimulation and virtual reality for walking in children with cerebral palsy
This study tests a treatment that uses a gentle electrical current on the scalp (called transcranial direct current stimulation) along with virtual reality exercises to help improve walking and self-esteem in children with spastic cerebral palsy.
IslamabadAges 8–16 - NCT07829770Recruiting
Brain stimulation with virtual reality for balance in cerebral palsy
This study tests a new type of brain stimulation combined with virtual reality exercises to see if it can improve balance and thinking skills in children with spastic diplegic cerebral palsy. The treatment is non-invasive and aims to help with everyday movement and cognitive function.
IslamabadAges 8–16 - NCT06478238RecruitingEarly Phase 1
Calcium folinate for hereditary spastic paraplegia type 56
This trial tests a drug called calcium folinate (a form of vitamin B9) to see if it can help people with a rare genetic type of spastic paraplegia (SPG56). It aims to improve leg stiffness and weakness caused by a specific gene change.
Shanghai, Shanghai MunicipalityAges Any age - NCT07803276RecruitingPhase 4
Injecting botox for stiff muscles: hands or ultrasound?
This study compares two ways of giving Botox injections to reduce muscle stiffness in people with spastic paraplegia: one uses the doctor's hands to find the injection spot, and the other uses ultrasound to guide the needle. The goal is to see if ultrasound guidance improves the results.
Rio de Janeiro, Rio de JaneiroAges 18 years+
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Common questions
- Are there clinical trials for spasticity?
- Yes. Clin2 currently lists 153 recruiting spasticity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a spasticity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a spasticity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.