Teriflunomide for HTLV-1 spinal cord stiffness and weakness
Treatments studied
Part of Brain & nervous system, Infections clinical trials.
This early-phase trial tests whether teriflunomide can help people with HTLV-1 associated myelopathy (HAM) or tropical spastic paraparesis (TSP). It also checks safety and how well the treatment can be followed over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be age 18 or older
- Have HAM/TSP confirmed by testing showing HTLV-1 (positive screening test and confirmatory blood test)
- Be enrolled in the specific related study group (98-N-0047)
- Be able and willing to take pills by mouth, follow visit schedules, and give informed consent
- Have a negative tuberculosis blood test (or complete treatment if it’s positive)
- Use reliable birth control if you could become pregnant or father a child, during treatment and for 2 years after stopping
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This research study evaluates people with HTLV infection, a virus that can cause a nerve disorder called HAM/TSP. Researchers want to better understand who gets this condition and why, which may help develop future treatments.
This study tests whether adding tenofovir (an antiviral medication) to dolutegravir helps treat HTLV-1 infection better than dolutegravir alone. HTLV-1 is a virus that can cause serious health problems, and researchers want to find the most effective treatment combination.
This trial tests whether a drug called mogamulizumab can prevent adult T-cell leukemia/lymphoma in people who carry the HTLV-1 virus and have a high viral load. It is for patients who have not yet developed the blood cancer.
This trial tests an investigational drug called telitacicept for people with inflammatory myopathy (muscle inflammation). It may help reduce muscle weakness and other symptoms when standard treatments haven't worked well enough.
This study looks at how the oral medication teriflunomide (Aubagio) affects tiredness and daily activities in people with relapsing forms of multiple sclerosis. If you are starting this treatment as part of your regular care, the study will track your experience over a year to see how it impacts your energy and function.
This trial tests if transplanting special cells into the spine is safe for people with transverse myelitis (a rare spinal cord inflammation) that has caused long-term weakness or trouble walking. It aims to see if these cells can help improve function.
Hear when a new HAM/TSP trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.