Gentamicin bone paste to treat stubborn long-bone bone infection
Part of Bones, joints & muscles, Infections clinical trials.
This study tests a bone filler/paste called Cerament-G that releases the antibiotic gentamicin directly at the infected bone site. It aims to improve treatment of chronic bone infection (chronic osteomyelitis) in long bones after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a long-bone bone infection in the tibia, femur, humerus, or forearm that has likely been going on for more than 3 months
- Your infection has signs on exam (like ongoing pain, a draining fistula, fluid, exposed bone, local swelling, or unexplained fever)
- Your infection also has matching imaging signs (such as bone changes on x-ray/CT, and possibly abscess or a track seen on MRI/CT if done)
- You can safely undergo the planned surgical treatment (cleaning bone, removing infected areas, and leaving a cavity to be treated, with follow-up antibiotic treatment planned for 3 months)
- If any hardware (metal) is present, it should be removable during surgery, and the wound can be closed safely without tension or with a tissue flap within 15 days
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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