Antibiotic plus bone-strengthening drug for bone infection
Treatments studied
Part of Bones, joints & muscles, Infections clinical trials.
This trial tests if adding a bone-strengthening drug (bisphosphonate) to standard antibiotic treatment (vancomycin) works better for a certain type of long-term bone infection (osteomyelitis) that needs surgery. It may help people with a staph infection in their thigh or shin bone who are otherwise fairly healthy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a long-term bone infection in your thigh or shin bone (doctors call this Cierny-Mader type I or III) and need surgery.
- Your infection is caused by Staph bacteria (including MRSA) that can be treated with vancomycin.
- You are between 18 and 65 years old.
- You are not taking bone-strengthening drugs now and have not had an IV version in the last year.
- Your kidneys are working well (creatinine below 177 μmol/L) and your calcium level is normal.
- You do not have poorly controlled diabetes (HbA1c under 8%) and are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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