Testing anti-HER2 treatment for HER2-enriched early breast cancer
Part of Cancer clinical trials.
This trial tests an anti-HER2 medicine in people whose breast cancer is classified as “HER2-enriched” using a special lab test (PAM50). It aims to see whether this treatment can help prevent or control cancer that cannot be fully removed by surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have breast cancer that cannot be fully removed (unresectable) or has spread, but there is no confirmed distant metastasis on scans/biopsy
- Your cancer must be HER2-negative by lab testing (either IHC 1+ without ISH, or IHC 2+ with ISH showing negative results)
- You must have never received systemic (whole-body) treatment for stage II–III breast cancer
- You must be over 19 years old and be able to do study visits (ECOG 0–1, meaning fully active or limited but ambulatory)
- Your blood, kidney, liver, and heart tests must meet safety thresholds (including heart pumping strength with LVEF ≥ 50%)
- A tissue test must confirm your subtype is “HER2-enriched” by PAM50, and you must have available archived slides (FFPE slides)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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