Venetoclax plus rituximab versus standard Waldenstrom treatment
Treatments studied
Part of Blood & lymphatic, Cancer, Heart & circulation, Immune system & allergy clinical trials.
This trial tests whether adding venetoclax to rituximab works better than standard treatment options for Waldenstrom’s macroglobulinemia (WM). It’s for adults whose WM needs treatment and who meet specific blood, organ, infection, and medication safety requirements.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of Waldenstrom’s macroglobulinemia (WM) / lymphoplasmacytic lymphoma (LPL).
- Your WM must have measurable activity, usually a high IgM protein level, checked within 28 days before enrolling.
- You must need treatment now (for example anemia, low platelets, nerve symptoms, very thick blood symptoms, kidney problems from WM, bulky disease, or certain ongoing symptoms).
- You must not have had chemotherapy-type treatment before; rituximab is allowed if your last dose was at least 6 months ago.
- Your body must be able to tolerate study medicine: kidney tests, liver tests, and blood counts must meet minimum levels, and you should be well enough to do daily activities (Zubrod 0–2).
- You must be able to take pills by mouth, have no major uncontrolled infections, and avoid certain drug interactions (including no grapefruit/Seville oranges/starfruit near the start).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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