Venetoclax plus rituximab for Waldenström’s macroglobulinemia
Part of Blood & lymphatic, Cancer, Heart & circulation, Immune system & allergy clinical trials.
This Phase 2 study tests whether the combination of venetoclax and rituximab works better for Waldenström’s macroglobulinemia (WM) than expected from standard approaches. It is for adults with WM who have symptoms or organ/health problems caused by the disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old and able to join the study willingly (sign informed consent).
- You must have a confirmed diagnosis of WM (tested on tissue samples within 4 months before starting treatment), and the study center must confirm it.
- You must have at least one WM-related problem such as fever/night sweats/weight loss/fatigue, swollen/bulky lymph nodes, high blood thickness, nerve symptoms, anemia/low platelets, kidney or amyloid problems, or high IgM/monoclonal protein levels.
- Your heart function must be good enough (left heart pumping strength—ejection fraction—about 40% or higher), and you must not have certain recent or unstable heart conditions.
- Your blood counts and organ tests must meet minimum levels (for example platelets and neutrophils above set thresholds; liver enzymes and bilirubin within limits; kidney filtration around 30 mL/min or higher).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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