Test drugs for HER2-negative advanced breast cancer
Part of Cancer, Skin clinical trials.
This Phase 1 trial tests a combination of immune-targeting drugs (a CD40 medicine and a substance that helps immune cells act) plus chemotherapy in people with HER2-negative advanced breast cancer that has progressed. It aims to find a safer dose and see whether the treatment can shrink tumors or slow the cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have stage III or stage IV breast cancer that is HER2-negative
- You are 18 years or older and able to do most daily activities (ECOG 0–2)
- Your cancer has gotten worse after your most recent cancer treatment
- You have recent blood test results that are safe enough (blood counts, kidney, liver values)
- You can have biopsies taken before starting and during treatment (and the site must be accessible)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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