Transcatheter repair for leaking mitral valve in high-risk patients
Part of Heart & circulation clinical trials.
This trial studies a minimally invasive device meant to fix a badly leaking mitral valve (mitral regurgitation) without open-heart surgery. It may be an option if you’re considered too high-risk for standard surgery and your heart anatomy fits the device.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe mitral valve leakage (mitral regurgitation), typically 3+ or worse
- You’re considered too high-risk for standard open-heart mitral surgery (for example, very high surgical risk or major risk factors)
- Your mitral valve problem is the kind this device targets: either “degenerative” leakage or “functional” leakage after standard heart medicines
- You are 18 or older, and you can understand the study, agree to consent, and do follow-up visits
- Your heart/valve shape is suitable for this “edge-to-edge” transcatheter repair using the SQ-Kyrin device
- You do not have key stop-sign conditions like severe mitral narrowing, major recent stroke, or certain anatomy shown on scans
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new device that replaces a leaking mitral valve without open-heart surgery. It may help people who have severe mitral valve leakage but cannot safely have standard surgery or some other less invasive valve repairs.
This study tests a new catheter-based system to treat severe mitral valve leaking when open-heart surgery is considered high risk. It may help improve blood flow and symptoms by repairing the valve without open surgery, using ultrasound guidance and follow-up visits to track safety and results.
This trial tests a catheter-based procedure to repair a leaking mitral valve in people who are in severe heart shock and need medication support. The goal is to reduce the valve leak and see if it helps patients stabilize and recover.
This trial tests a new device called the Capstan system to fix a leaky mitral valve (mitral regurgitation) without open-heart surgery. It may help people whose valve leak is moderate to severe and still have symptoms despite medicines.
This trial studies a newer, catheter-based mitral valve treatment in people with moderate-severe to severe mitral valve leaking who are at high risk for open-heart surgery. It may help improve symptoms and heart function without traditional surgery, but you must meet key heart, anatomy, and safety requirements.
This trial tests Valveclip, a catheter-based way to repair a mitral valve that is leaking badly. It may help people who are high-risk for open surgery by aiming to reduce the leak with a less invasive approach.
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