Clinical trials
Mitral Regurgitation clinical trials
Below are recruiting mitral regurgitation clinical trials, each written for real people, not researchers. We’re tracking 102 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07470788Recruiting
Vesalius TMVr system for leaky heart valve (mitral regurgitation)
This study tests a new device called the Vesalius TMVr system to fix a leaky mitral valve without open-heart surgery. It's for people with severe mitral regurgitation who are not good candidates for surgery.
VancouverAges 19 years+ - NCT04733404Recruiting
Dragonfly device study for functional mitral valve leakage
This trial tests a catheter-based procedure (putting a small device through blood vessels) to repair a leaking mitral valve caused by heart muscle problems. It aims to reduce symptoms and improve heart function and safety in people who are still having heart failure symptoms despite standard treatment.
Hangzhou, ZhejiangAges 18 years+ - NCT06467110Enrolling by invitation
Study of SQ-Kyrin TMVr System for leaky mitral valve
This trial tests a new device called the SQ-Kyrin TMVr System to treat severe mitral regurgitation (a leaky heart valve) in people who are not good candidates for traditional open-heart surgery. The goal is to repair the valve without major surgery, using a catheter-based approach.
Shenyang, LiaoningAges 18 years+ - NCT06465745Recruiting
AltaValve study for leaky mitral valve
This trial tests a new, less invasive device called the AltaValve to treat a leaky mitral valve. It is for people whose leak is severe enough to cause symptoms, but who cannot have standard surgery or a clip procedure.
Phoenix, ArizonaAges 18 years+ - NCT03242642Recruiting
Testing a new catheter procedure to replace a leaking mitral valve
This trial studies whether a new catheter-based system can replace a badly leaking mitral valve in people who have symptoms. It may help if you can’t safely get current approved valve treatments or standard surgery.
Birmingham, AlabamaAges 18 years+ - NCT03975998Recruiting
Early mitral valve repair versus watchful waiting
This trial compares doing mitral valve repair early with closely monitoring symptoms instead, for people who have severe leakage but feel well. It may help determine whether early surgery prevents future heart problems without causing unnecessary risk.
AmsterdamAges 18–75 - NCT05610566Recruiting
HighLife valve replacement for severe leaking mitral valve
This trial studies a new catheter-based valve replacement system for people with moderate to severe, or severe, mitral valve regurgitation (a leaky mitral valve). It aims to check whether the procedure is safe and can improve heart function compared with expected care.
Suzhou, JiangsuAges 18 years+ - NCT05655897Recruiting
Clips for leaky mitral valve in high-surgery-risk heart patients
This trial studies whether a device called GeminiOne can safely and effectively repair a leaky mitral valve using a catheter-based “clip” technique. It may help patients who have moderate-to-severe or severe valve leakage but are considered too high-risk for open surgery.
Suzhou, JiangsuAges 18 years+ - NCT05920824Recruiting
Testing treatment for leaking mitral and tricuspid valves
This trial studies people with atrial fibrillation and moderate-to-severe leakiness in the mitral and tricuspid valves in the heart. It likely aims to improve symptoms and heart function by better addressing how these valve leaks happen.
LondonAges 18 years+ - NCT06911099Recruiting
Studying mitral valve repair for atrial regurgitation
This trial tests a minimally invasive procedure (transcatheter edge-to-edge repair) to fix a leaky mitral valve caused by an enlarged atrium, not by heart muscle damage. It might be an option if your mitral regurgitation is related to atrial issues and your heart's pumping strength is normal.
The Bronx, New YorkAges 18 years+ - NCT07069673Recruiting
Abbott Cephea mitral valve disease registry
This study tracks people with mitral valve disease who receive the Cephea valve through a tube in an artery rather than open-heart surgery. It looks at how well the valve works over time.
Birmingham, AlabamaAges 18 years+ - NCT07097740Recruiting
Study of a new polymer heart valve for mitral or aortic replacement
This study tests a new type of prosthetic heart valve made from a special polymer material. It is for adults who need surgical replacement of either the mitral or aortic valve.
Shanghai, Shanghai MunicipalityAges 50 years+ - NCT05677568Enrolling by invitation
Registry study for Carillon device in leaky mitral valve
This registry collects health information from adults who already have the Carillon device to treat a leaky mitral valve caused by dilated heart muscle. The goal is to better understand how the device performs in real-world care over time.
AachenAges 18 years+ - NCT05090540Enrolling by invitation
Less Invasive vs Usual Surgery for Mitral Valve Leaks
This trial compares a less invasive catheter procedure to the standard surgical operation to treat “secondary” leaking of the mitral valve. It may help people with significant valve leak decide which approach works better for reducing symptoms and heart strain.
Saint-DenisAges 18–90 - NCT03389542Recruiting
Early mitral valve repair versus watchful waiting
This trial compares doing mitral valve repair early versus closely monitoring without surgery in people who have severe leakage but no symptoms. It aims to see whether early repair helps prevent future heart problems.
AmiensAges 18–75 - NCT06823700Recruiting
Study of SQ-Kyrin device for leaky mitral valve from heart failure
This trial tests a new device (SQ-Kyrin) to fix a leaky mitral valve without open-heart surgery. It is for people with heart failure whose valve leak causes symptoms, and who are not good candidates for traditional surgery.
Valladolid, ValladolidAges 18 years+ - NCT04029363Recruiting
Transcatheter mitral valve procedure for high-surgery-risk patients
This trial studies a newer, catheter-based mitral valve treatment in people with moderate-severe to severe mitral valve leaking who are at high risk for open-heart surgery. It may help improve symptoms and heart function without traditional surgery, but you must meet key heart, anatomy, and safety requirements.
Darlinghurst, New South WalesAges 18 years+ - NCT04500899RecruitingPhase 1/Phase 2
Phenylephrine test to better grade mitral valve leak severity
This trial tests whether a medication called phenylephrine helps doctors measure how severe mitral regurgitation (mitral valve leak) is. If you’re already scheduled for a special ultrasound from the esophagus, this study may help improve how your valve leak is assessed.
New York, New YorkAges 18 years+ - NCT05469165RecruitingPhase 2
Testing serotonin blockers after a first heart attack
This Phase 2 trial tests whether blocking serotonin receptors can help after a first heart attack that has caused a specific type of leaking mitral valve problem. It aims to see if the treatment improves heart function and heart-valve measurements while keeping patients safe.
QuébecAges 18–80 - NCT06876883Recruiting
Mitral regurgitation risk assessment study
This study looks at people with moderate or severe mitral regurgitation (a leaky heart valve) to better understand their risks and create models to guide treatment. It may help your doctor decide on the best care plan for you.
Guangzhou, GuangdongAges 18 years+ - NCT04408430Recruiting
Valve replacement for severe mitral valve disease in high-risk adults
This trial tests a less-invasive way to treat severe mitral valve problems using a transcatheter valve. It may help people who are too high-risk for standard open-heart mitral surgery by improving symptoms and heart function.
Gilbert, ArizonaAges 18 years+ - NCT04688190Recruiting
Registry study for choosing a mitral valve treatment
This study collects and compares real-world results to help doctors choose the best treatment for mitral valve “leakiness.” If you have clinically significant mitral insufficiency and have already had a specific heart procedure screening, your echocardiogram results may be used to understand outcomes over at least a month.
Tucson, ArizonaAges 18 years+ - NCT04577248Recruiting
Heart valve registry for people considering valve procedures
This study follows adults with leaky or narrowed heart valves who are being considered for a valve procedure. It helps doctors better understand patient outcomes and care decisions for these valve problems.
Munich, BavariaAges 18–110 - NCT05310461Recruiting
Early or delayed valve surgery for mixed heart valve disease
This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.
BernAges 18 years+
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Mitral Regurgitation trials by city
Studies with a site in or near these metro areas.
Mitral Regurgitation trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for mitral regurgitation?
- Yes. Clin2 currently lists 102 recruiting mitral regurgitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mitral regurgitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mitral regurgitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.